Publications using Protein Macroarray Technology

(Please note that engine GmbH is the legal successor of Source Biosciences, imaGenes, RZPD)

Almamy A, Schwerk C, Schroten H, Ishikawa H, Asif AR, Reuss B. Crossreactivity of an Antiserum Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae with the SNARE-Complex Protein Snap23 Correlates to Impaired Exocytosis in SH-SY5Y Cells. J Mol Neurosci. 2017;62: 163–180. doi:10.1007/s12031-017-0920-2

Leidinger P, Keller A, Milchram L, Harz C, Hart M, Werth A, et al. Combination of autoantibody signature with PSA level enables a highly accurate blood-based differentiation of prostate cancer patients from patients with benign prostatic hyperplasia. PLoS One. 2015;10: 1–14. doi:10.1371/journal.pone.0128235

Preuss KD, Pfreundschuh M, Fadle N, Regitz E, Kubuschok B. Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor. J Clin Invest. 2015;125: 316–323. doi:10.1172/JCI76802

Tellermann A, Witte T, Lansche C, Stoll M, Schmidt R, Baerlecken NT. Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections. HIV Med. 2015;16: 114–121. doi:10.1111/hiv.12194

Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, et al. Autoantibodies against CD74 in spondyloarthritis. Ann Rheum Dis. 2014;73: 1211–1214. doi:10.1136/annrheumdis-2012-202208

Bloch DB, Li P, Bloch EG, Berenson DF, Galdos RL, Arora P, et al. LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. PLoS One. 2014;9. doi:10.1371/journal.pone.0094784

Baerlecken NT, Pursche N, Witte T, Schmidt RE, Hoepfner M, Moosig F. Antiboies Against Drp-4 and Macropain Subunit C2 As a Potential Marker OF Aosd [abstract]. Arthritis Rheum 2013. 2013. doi:10.1002/art.2013.65.issue-s10

Baerlecken NT, Witte T, Schmidt RE, Lansche C, Bernateck M, Pursche N. IgG Autoantibodies Against p29ING4 In Early-Stage Type I Complex Regional Pain Syndrome (CRPS) and In Other Inflammatory Diseases Involving The Joints [abstract]. Arthritis Rheum 2013. 2013. doi:10.1002/art.2013.65.issue-s10

Becker A, Ludwig N, Keller A, Tackenberg B, Eienbröker C, Oertel WH, et al. Myasthenia gravis: analysis of serum autoantibody reactivities to 1827 potential human autoantigens by protein macroarrays. PLoS One. 2013;8: e58095. doi:10.1371/journal.pone.0058095

Martínez FP, Tang Q. Identification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay. Viruses. 2013;6: 89–105. doi:10.3390/v6010089

Hoepfner M, Witte T, Pursche N, Moosig F, Gross W, Schmidt RE, et al. Antibodies binding to DRP-4 and macropain subunit C2 as a potential marker of AOSD. Annu Eur Congr Rheumatol Eur Leag Against Rheum EULAR 2013 Madrid Spain. 2013;72: 1–2. doi:10.1136/annrheumdis-2013-eular.1017

Bader V, Tomppo L, Trossbach S V., Bradshaw NJ, Prikulis I, Rutger Leliveld S, et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet. 2012;21: 4406–4418. doi:10.1093/hmg/dds273

Murphy M a., O’Connell DJ, O’Kane SL, O’Brien JK, O’Toole S, Martin C, et al. Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays. J Proteomics. 2012;75: 4668–4675. doi:10.1016/j.jprot.2012.02.031

Baerlecken NT, Linnemann a., Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay M a., et al. Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. Ann Rheum Dis. 2012;71: 943–947. doi:10.1136/annrheumdis-2011-200413

Backes C, Ludwig N, Leidinger P, Harz C, Hoffmann J, Keller A, et al. Immunogenicity of autoantigens. BMC Genomics. 2011;12: 340. doi:10.1186/1471-2164-12-340

Bauer MC, O’Connell DJ, Maj M, Wagner L, Cahill DJ, Linse S. Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. Mol Biosyst. 2011;7: 2196–2204. doi:10.1039/c0mb00349b

Arthur JF, Shen Y, Gardiner EE, Coleman L, Kenny D, Andrews RK, et al. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011;9: 163–172. doi:10.1111/j.1538-7836.2010.04091.x

Pless O, Kowenz-Leutz E, Dittmar G, Leutz A. A differential proteome screening system for post-translational modificationg-dependent transcription factor interactions. Nat Protoc. 2011;6: 359–364. doi:10.1038/nprot.2011.303

Schmitt J, Keller A, Nourkami-Tutdibi N, Heisel S, Habel N, Leidinger P, et al. Autoantibody signature differentiates wilms tumor patients from neuroblastoma patients. PLoS One. 2011;6: 8–14. doi:10.1371/journal.pone.0028951

Olsson N, Wingren C, Mattsson M, James P, O’ Connell D, Nilsson F, et al. Proteomic Analysis and Discovery Using Affinity Proteomics and Mass Spectrometry. Mol Cell Proteomics. 2011;10: M110.003962-M110.003962. doi:10.1074/mcp.M110.003962

Kijanka G, Hector S, Kay EW, Murray F, Cummins R, Murphy D, et al. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. Gut. 2010;59: 69–78. doi:10.1136/gut.2009.178574

Fenner BJ, Scannell M, Prehn JHM. Expanding the substantial interactome of NEMO using protein microarrays. PLoS One. 2010;5. doi:10.1371/journal.pone.0008799

O’Connell DJ, Bauer MC, O’Brien J, Johnson WM, Divizio C a, O’Kane SL, et al. Integrated protein array screening and high throughput validation of 70 novel neural calmodulin-binding proteins. Mol Cell Proteomics. 2010;9: 1118–1132. doi:10.1074/mcp.M900324-MCP200

Raab M, Daxecker H, Edwards RJ, Treumann A, Murphy D, Moran N. Protein interactions with the platelet integrin aIIb regulatory motif. Proteomics. 2010;10: 2790–2800. doi:10.1002/pmic.200900621

Leidinger P, Keller A, Heisel S, Ludwig N, Rheinheimer S, Klein V, et al. Identification of lung cancer with high sensitivity and specificity by blood testing. Respir Res. 2010;11: 18. doi:10.1186/1465-9921-11-18

Kowenz-Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. Nature Publishing Group; 2010;29: 1105–1115. doi:10.1038/emboj.2010.3

Yumerefendi H, Tarendeau F, Mas PJ, Hart DJ. ESPRIT: An automated, library-based method for mapping and soluble expression of protein domains from challenging targets. J Struct Biol. Elsevier Inc.; 2010;172: 66–74. doi:10.1016/j.jsb.2010.02.021

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, et al. Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci. 2010;51: 2968–75. doi:10.1167/iovs.09-4898

Ludwig N, Keller A, Heisel S, Leidinger P, Klein V, Rheinheimer S, et al. Improving seroreactivity-based detection of glioma. Neoplasia. 2009;11: 1383–9. doi:10.1593/neo.91018

Fenner BJ, Scannell M, Prehn JHM. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochim Biophys Acta. Elsevier B.V.; 2009;1794: 1010–1016. doi:10.1016/j.bbapap.2009.02.013

Kijanka G, Barry R, Chen H, Gould E, Seidlits SK, Schmid J, et al. Defining the molecular target of an antibody derived from nuclear extract of Jurkat cells using protein arrays. Anal Biochem. 2009;395: 119–124. doi:10.1016/j.ab.2009.08.039

Kijanka G, IpCho S, Baars S, Chen H, Hadley K, Beveridge A, et al. Rapid characterization of binding specificity and cross-reactivity of antibodies using recombinant human protein arrays. J Immunol Methods. Elsevier B.V.; 2009;340: 132–137. doi:10.1016/j.jim.2008.10.008

Kijanka G, Murphy D. Protein arrays as tools for serum autoantibody marker discovery in cancer. J Proteomics. Elsevier B.V.; 2009;72: 936–944. doi:10.1016/j.jprot.2009.02.006

Leidinger P, Keller A, Heisel S, Ludwig N, Rheinheimer S, Klein V, et al. Novel autoantigens immunogenic in COPD patients. Respir Res. 2009;10: 20. doi:10.1186/1465-9921-10-20

Lukong KE, Richard S. Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cell Signal. 2008;20: 432–442. doi:10.1016/j.cellsig.2007.11.003

Pandithage R, Lilischkis R, Harting K, Wolf A, Jedamzik B, Lüscher-Firzlaff J, et al. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol. 2008;180: 915–929. doi:10.1083/jcb.200707126

Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, et al. G9a-mediated lysine methylation alters the function of CCAAT/Enhancer- binding protein-β. J Biol Chem. 2008;283: 26357–26363. doi:10.1074/jbc.M802132200

Yang W-H, Bloch DB. Probing the mRNA processing body using protein macroarrays and “autoantigenomics”. RNA. 2007;13: 704–12. doi:10.1261/rna.411907

Horn S, Lueking A, Murphy D, Staudt A, Gutjahr C, Schulte K, et al. Profiling humoral autoimmune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip. Proteomics. 2006;6: 605–613. doi:10.1002/pmic.200401293

Lenze D, Berg E, Volkmer-Engert R, Weiser AA, Greiner A, Knörr-Wittmann C, et al. Influence of antigen on the development of MALT lymphoma. Blood. 2006;107: 1141–1148. doi:10.1182/blood-2005-04-1722

Zhang W, Huang J, Zhou M-F, Chen L-Y, Ding Y-P, Cao H-J, et al. Protein Chip for Detection of Different HCV Antibodies. Mol Diagnosis. 2005;9: 81–87. doi:10.2165/00066982-200509020-00004

Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Büssow K, et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest. 2005;115: 1352–1360. doi:10.1172/JCI200523661.1352

Grelle G. Identification of VCP/p97, Carboxyl Terminus of Hsp70-interacting Protein (CHIP), and Amphiphysin II Interaction Partners Using Membrane-based Human Proteome Arrays. Mol Cell Proteomics. 2005;5: 234–244. doi:10.1074/mcp.M500198-MCP200

Büssow K, Scheich C, Sievert V, Harttig U, Schultz J, Simon B, et al. Structural genomics of human proteins--target selection and generation of a public catalogue of expression clones. Microb Cell Fact. 2005;4: 21. doi:10.1186/1475-2859-4-21

Gutjahr C, Murphy D, Lueking A, Koenig A, Janitz M, O’Brien J, et al. Mouse protein arrays from a TH1 cell cDNA library for antibody screening and serum profiling. Genomics. 2005;85: 285–296. doi:10.1016/j.ygeno.2004.11.005

Lueking A, Huber O, Wirths C, Schulte K, Stieler KM, Blume-peytavi U, et al. Profiling of Alopecia Areata Autoantigens Based on Protein Microarray Technology *. 2005; 1382–1390. doi:10.1074/mcp.T500004-MCP200

Lueking A, Cahill DJ, Müllner S. Protein biochips: A new and versatile platform technology for molecular medicine. Drug Discov Today. 2005;10: 789–794. doi:10.1016/S1359-6446(05)03449-5

Büssow K, Quedenau C, Sievert V, Tischer J, Scheich C, Seitz H, et al. A catalog of human cDNA expression clones and its application to structural genomics. Genome Biol. 2004;5: R71. doi:10.1186/gb-2004-5-9-r71

Kramer A, Feilner T, Possling A, Radchuk V, Weschke W, Bürkle L, et al. Identification of barley CK2α targets by using the protein microarray technology. Phytochemistry. 2004;65: 1777–1784. doi:10.1016/j.phytochem.2004.04.009

De Graaf K, Hekerman P, Spelten O, Herrmann A, Packman LC, Büssow K, et al. Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain. Phosphorylation by DYRK1a and colocalization with splicing factors. J Biol Chem. 2004;279: 4612–4624. doi:10.1074/jbc.M310794200

Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004;23: 5049–55. doi:10.1038/sj.onc.1207680

Maercker C. Protein-Chips in der Genomforschung. Laborwelt. 2004; 12–15.

Radelof, U., Hüls, C., Korn, B., Maurer J. Proteinarrays und rekombinante Proteine für die Proteinanalyse. Labor Welt. 2004;5: 35.

Will J. Charakterisierung der Interaktion der humanen Histon-Deacetylase 3 mit der MAP Kinase 11. 2004. doi:10.1007/s13398-014-0173-7.2

Lueking A, Possling A, Huber O, Beveridge A, Horn M, Eickhoff H, et al. A Nonredundant Human Protein Chip for Antibody Screening and Serum Profiling. Mol Cell Proteomics. 2003;2: 1342–1349. doi:10.1074/mcp.T300001-MCP200

Holz C, Hesse O, Bolotina N, Stahl U, Lang C. A micro-scale process for high-throughput expression of cDNAs in the yeast Saccharomyces cerevisiae. Protein Expr Purif. 2002;25: 372–378. doi:10.1016/S1046-5928(02)00029-3

Piontek J, Régnier-Vigouroux A, Brandt R. Contact with astroglial membranes induces axonal and dendritic growth of human CNS model neurons and affects the distribution of the growth-associated proteins MAP1b and GAP43. J Neurosci Res. 2002;67: 471–483. doi:10.1002/jnr.10094

Schmidt F, Lueking A, Nordhoff E, Gobom J, Klose J, Seitz H, et al. Generation of minimal protein identifiers of proteins from two-dimensional gels and recombinant proteins. Electrophoresis. 2002;23: 621–625. doi:10.1002/1522-2683(200202)23:4<621::AID-ELPS621>3.0.CO;2-J

Fischer A. Biochemische Charakterisierung der basischen Hey1 und Hey2 sowie Untersuchung ihrer Rolle während der Herz- und Gefässentwicklung. Julius-Maximilian-Universität zu Würzburg. 2002.

Lee J, Bedford MT. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep. 2002;3: 268–273. doi:10.1093/embo-reports/kvf052

de Wildt RMT, Tomlinson IM, Ong JL, Holliger P. Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes. Proc Natl Acad Sci U S A. 2002;99: 8530–8535. doi:10.1073/pnas.132008499

Cahill DJ. Protein and antibody arrays and their medical applications. J Immunol Methods. 2001;250: 81–91. doi:10.1016/S0022-1759(01)00325-8

Büssow K, Konthur Z, Lueking A, Lehrach H, Walter G. Protein Array Technology. Am J PharmacoGenomics. 2001;1: 37–43. doi:10.2165/00129785-200101010-00005

Schreiber S, Hampe J, Eickhoff H, Lehrach H. Functional genomics in gastroenterology. Gut. 2000;47: 601–607. doi:10.1136/gut.47.5.601

Lueking A, Holz C, Gotthold C, Lehrach H, Cahill D. A System for Dual Protein Expression in Pichia pastoris and Escherichia coli. Protein Expr Purif. 2000;20: 372–378. doi:10.1006/prep.2000.1317

Büssow K, Nordhoff E, Lübbert C, Lehrach H, Walter G. A human cDNA library for high-throughput protein expression screening. Genomics. 2000;65: 1–8. doi:10.1006/geno.2000.6141

Holt LJ, Büssow K, Walter G, Tomlinson IM. By-passing selection: direct screening for antibody-antigen interactions using protein arrays. Nucleic Acids Res. 2000;28: E72. doi:10.1093/nar/28.15.e72

Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, et al. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res. 1998;26: 5007–8. doi:10.1093/nar/26.21.5007

To download a recent list of publications using protein macroarrays click here.